ࡱ> y R~Lbjbj2l{{1 22222FFF8~Z4F't6$Z&&&&&&&$})/,<'-2nnn'224;'& n|22N& n& ]K*j :&a'<' k,k, k,2 xnn nnnnn'' nnn'nnnnk,nnnnnnnnn, : DN 227 v8T6eSOQՋel Skin Absorption: in Vvivo Method 1 V ,gelĉ[NSYTSev8T6eSOQՋelv/g틌T[IN0ՋSR0Ջel0ՋpencTbJT0 ,gel(uNSYTSe~v8T6evSOQՋ0 ,gՋel(uNUSNbRvSYTSe ^USNbRvSeO(u,gelۏLċN cOfYvyf[OncfvQSL'`0 2 Ջvv ,gelNSYTSe~v8T6evSOQՋel NO:NSYTSevk'`R{|0h~{hƋT^(ucOՋOnc0 3 [IN 3.1 *g8T6eBRϑ unabsorbed dose gkT Nvhbm1 NegvTD@w(Wnvňn NSՋirvϑ ؏Sb(WgkǏ z-NNvhb%cSvϑ0 3.2 8T6eBRϑSOQ absorbed dosein vivo SdSՋMOvvSՋirT Sb(W?\m0<{wQQmm0|O0|TQlSO gKmՋ 0@m0Ty~~ gǑƖ NSOYu(W8\SO-NSՋirvϑ0 3.3 S8T6eBRϑabsorbable dose vQmT X[Yu(Wvhbbv~~QSՋirvϑ0 4 ՋvW,gSR SՋirg}Y(u>e\'` TMO }h e(uNRirSkvv N Ջ[wQ gNh'`vN*NbY*NBRϑ~0(W[vgkeQ Ǒ(u[v^\0JS\_b\_ nvňnvgkMON2bkRirՋ7hT v^SՋ6RYirNRirvc~cgkNke0(Wgk~_ge Sdnvňnv^(u[vnmBRnmRirv OYu(uǏvnvňnTnmmNYRgKm[ v^bc Nevnvňn0(WgkMR0gkgTgk~_gT ՋRirGW(WUSrvN"<{-Nr{Q v^6eƖvQclirT|TQlSONYRgKm[0Yg gEQvnchfg\Nub NNu%cS'`v>e\'`N"Nir RSN N6eƖRir|TQlSO08^ k*NBRϑ~QQ*NRirՋ~ N~(Wgk~_gTzsSY{k vQN~O!k(W[epY{k0kN*NǑ7hepY{kvՋRir [ǑƖ@7hNSSՋMOvۏLRg v^RgRir8\SONnx[*gclvSՋirvϑ0ǑƖv7hTNS_velۏLRg v^[SՋir~v8T6ev z^ۏLċ0O0 5 Ջel 5.1 SՋir SՋir/fc(uNxvzvQnyr'`vir(0SՋirg}Y(u>e\'` TMO }h0 6RYvSՋirSb~T0zʑTbvce(uNvvS+TSՋirv6RYir ^NNSObvQN\o(Wvhy^\Svf2b_`Nb/ft`vfNir 6RYǏ z-NQsNUO N TN[EO(u`b_v9eS_{ gEQRvt1u0_e SՋirSnb`nmNS_vnZ-N [N^4l'`nZ ^NvQ8T6eyr'`NSNSՋirv\o(WvN\O(u0 5.2 [RirTr{QsX 5.2.1 Ririry0T|v b 'Y /fg8^(uy^\ FO_NSO(uv8T6esNN{|fvfv'`+R]_ R^ (ufOeav'`+R &TRSN Ny0 5.2.3 r{QsX [RirS[Rir?b^&{TV[v^ĉ[0 (uhQMTre n4l NP6R0 Ջgg}Y_NSbՋKNMRv^g Rir^(WN"<{-NUS<{r{Q =\ϑMQߘirT4lnQ[hVq_TՋ~g0 5.3 Ջek 5.3.1 ՋRirvQY Ջ_YMR kSRir^ZP}YhRN:S+R v^(WTꁄv<{wQ-N\r{Q5)YN^[sX0 6qT (WgkMR~24 h \kSRir萌T̀@\萮vSk v^(uNn{{dbvhbNSdv VvkYuir gSOۏv[KmՋirv8T6e Ee NcP(uv4lnmv0CRkby^Y'Y NnxOS`0W{Qks^eSs|v[SՋirv8T6eϑ CRkvby^\:N10 cm2 by[NSO͑(W 200 g~250 gVQv'Y /f[v0RirQY[bT ͑e>eVN"<{0 5.3.2 vgk (Wvhbnx[yr[byvSՋMO \]wϑvSՋ6RYirGWS0WmbNMO0(uϑ8^^Ǒ(uNSOSvcϑ VSOSՋir8^:N1~5 mg/cm2 mSOSՋirgYS10 L/cm20S9hncSՋirgvO(u`Q0xvzvvNSirt'`(tegkBRϑ FO^ gS_t1u0gkT SՋMO^MQ扰x08^ SՋMO^Ǒ(u^TvnvňnvYl<\~^i xQWňnv:yOYV1@b:y0gNyr[`Q N SՋMO^ǑST'`Ob0JS%cS'`KmՋir(v%cS[SՋirvV6esQScSvVS5.4 ^(WSՋirňn Nv;m'`pǏnhVNUc%cSvSՋirV1 0NUOvňn N^_c$Ov _N N8T6ebNSՋ6RYirSuS^0gkT \Rir>eVUSrvN"<{-NNO6eƖclir0  V1 Ny(uNvTObSՋMOvvxQWnvňn:yOV 5.3.3 gkeTS7h gkg/fc(Wv_YcSՋir nmSdSՋirKNve0@bǑ(uvgkeN,:N6 hb24 h ^N8^NSOSvcev[^0gk~_gT \Rirr{QNN"<{-NOYuv󁄘[vY{kep0gk~_gT ^[SՋvۏL‰[v^U_NUOSv:Rour0  $BHLNPVdfhǭueuQ7ueu*hTfhyOJQJaJ2hchh!OJPJQJaJcHdh‡o(&Hh‡h!OJPJQJaJo(hchOJPJQJaJo(hchyOJPJQJaJ#hchyCJ OJPJQJaJ o(-Hh%Gh*CJKHOJPJQJ]o(3hNXh*CJKHOJPJQJ]cHdh%Go(0hjh*CJKHOJPJQJ]cHdh%GhjCJKHOJPJQJ] hjCJKHOJPJQJ]o($frn ~ ( wd,1$WD`gd,Ld,1$XD2YD2gd} d,XD2YD2[$\$gd'd,1$WD`gdTfd,1$XD2YD2gdTf$d,XD2YD2a$gd& $d,XD2YD2a$gd'$$$d,@&a$gdj hjlpn r t | ~   & ( . 0 6 : D Ÿ㩸s^SSSh,LOJQJaJo((hTfhyCJKHOJPJQJ^JaJ%hc@CJOJPJQJ^JaJo((hchy@CJOJPJQJ^JaJhTfhOJQJaJo(hTfhyOJPJQJaJhTfhyOJQJaJhTfhpOJQJaJo(hTfhyOJPJQJaJo(hTfhcOJQJaJo(hTfhyOJQJaJo(D F L N P \ ~       2 6 @ F J R Z d 㜉%hc@CJOJPJQJ^JaJo((hchy@CJOJPJQJ^JaJh} OJQJaJo(hTfhH{=OJQJaJo(hTfhRqOJQJaJo(h,LOJQJaJo(hTfhyOJQJaJo(hTfhOJQJaJo(0 Z .t,D$d,[$\$a$gd'$d,XD2YD2[$\$a$gdCd,1$WD`gdTfd,XD2YD2[$\$gd'd,1$WD`gd} d,1$XD2YD2gd} d,1$WD`gd,L $ 2 p r t x z    * , 4 6 8 ȺȺȺȐȺȺȺȂȂȞȞȞttfthTfh/j!OJQJaJo(hTfh}xOJQJaJo(hTfhAOJQJaJo(hTfh6OJQJaJo(hTfhNOJQJaJo(hTfhv OJQJaJo(hTfhM@EOJQJaJo(hTfhyOJQJaJo((hchy@CJOJPJQJ^JaJ(hTfhyCJKHOJPJQJ^JaJ(8 < > >NRTdhntz| Տzg%hc@CJOJPJQJ^JaJo((hchy@CJOJPJQJ^JaJhTfhFOJQJaJo(hTfhv OJQJaJo(hTfhJOJQJaJo(hTfh6vOJQJaJo(hTfhp OJQJaJo(hTfh/j!OJQJaJo(hTfhyOJQJaJo(hTfh}xOJQJaJo(($&,.4^`fltz òÒxxkkkkkkk^k^k^hTfhCOJQJaJhTfh`dOJQJaJhTfhv OJQJaJhTfhmOJQJaJhTfhyOJQJaJ$hChy@CJOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJ(hchy@CJOJPJQJ^JaJ(hTfhyCJKHOJPJQJ^JaJ (,8@HRVXbfntv|~$(,6̿欛uhh[hhTfhQOJQJaJhTfhkOJQJaJ$hTfhyCJKHOJQJ^JaJ$hChy@CJOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJhTfhHOJQJaJhTfhAQ}OJQJaJhTfhCOJQJaJhTfhyOJQJaJhTfhr OJQJaJ#6:^怳m\Im$hTfhyCJKHOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJhTfh OJQJaJhTfhG]OJQJaJhr3OJQJaJo(hTfh-OJQJaJo(hTfhy$OJQJaJ#h?<B*KHOJQJ_HaJph&h?<B*KHOJQJ_HaJo(phhTfhyOJQJaJhTfhkOJQJaJ$&*248:@BNd ,6:BDپپٰ٥٘٘٘مta$hTfhyCJKHOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJhTfhnvOJQJaJh4OJQJaJo(hTfhcOJQJaJo(hTfhRyOJQJaJo(hTfhrOJQJaJhTfhyOJQJaJhTfhbKOJQJaJhTfheS OJQJaJ&D$&@DFHJR^bltx|̿ٲٟ{h[[[[[[hTfhoGOJQJaJ$hTfhyCJKHOJQJ^JaJ$hChy@CJOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJhTfhHOJQJaJhTfhYqOJQJaJhTfhOJQJaJhTfhyOJQJaJhr^`OJQJaJo(hr^`hr^`OJQJaJo(D&|>`?6@AA:DE$d,XD2YD2[$\$a$gd'd,WD[$\$`gd'$d,[$\$a$gd'$d,XD2YD2[$\$a$gdCd,1$WD`gdTf|~ $(*46@DFTVdfv澱旉{ph[ OJQJaJo(hTfh-OJQJaJo(hTfhZ%H*OJQJaJhTfhZ%OJQJaJhTfhfyQOJQJaJhTfhbOJQJaJhTfhgTZOJQJaJo(hTfhYqOJQJaJhTfh@-OJQJaJhTfhyOJQJaJhTfhOJQJaJ'$.268@BLNVZ^hlv~Ƶ|nn|hTfh-OJQJaJo(hTfhyH*OJQJaJhSDzOJQJaJo(hTfh^OJQJaJ$hTfhyCJKHOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJhTfhfyQOJQJaJhTfhyOJQJaJhTfhcOJQJaJ&^`tx|~$8<DFPRZ̥̲̲̲̿̿~qdqhTfhElOJQJaJhTfh^OJQJaJhTfhhXOJQJaJhTfhDjlOJQJaJhTfhhOJQJaJhTfhnOJQJaJhTfhdpOJQJaJhTfhyOJQJaJhTfhCOJQJaJhTfhDOJQJaJhTfh(5OJQJaJhTfhYJOJQJaJ$Zdnv¨y___yL;L!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJ3h#chFCJOJPJQJ^J_HaJmHo(sH+h'hy@CJOJPJQJ^JaJo(0h#chyCJOJPJQJ^J_HaJmHsH3h#chyCJOJPJQJ^J_HaJmHo(sHhy@^Jo(jhy@U^Jo(hTfh)OJQJaJhTfhyOJQJaJhTfhMOJQJaJ"*0@PRVZ^dfhj>>>>> >ǺzmmmmmkmmUhTfhFOJQJaJhTfh{JOJQJaJhTfhgTZOJQJaJo(hBR*OJQJaJo(hTfhn4OJQJaJhTfhyOJQJaJhTfh4HcOJQJaJ$hchy@CJOJQJ^JaJ$h8 h4HcCJKHOJQJ^JaJ$h8 hyCJKHOJQJ^JaJ$ (Wte*NxvzǏ z-N ^Ǒ(uN"<{R+R6eƖ?\mT|O v^S(W14C-hvN'lSxT%cS'`14CSTir>5% NueۏL6eƖT[ϑRg0?\m0|OTUcmY14ChvN'lSxT%cS'`14CSTir ^(Wk*NS7hepNk~-NUSr6eƖ0 gYvDef_\bQNN NNu>e\'`N"ir RSǑ(u_>e_<{g0te*NՋg ^[g‰[Rirvk'`b_8^S^0 gkg N_YvcT24 hNSTvkN)Y GW^6eƖclirvՋ~_g0N, ǑƖ N*Nepvclir8^1\YN FOgNSՋ6RYirvyr_bs gRRf[pencSOBl gf[0bfYv6eƖepNOxvz0 gk~_ge NkSRir NySObňnv^USrOYuNOՋRg0@b gRirvSՋMOv^(u[vh~{8SnmBRnm\3!k _{laMQalgvQNMO0nmBR^:Nv4lI{ gNh'`v8^(ukSunmBR0gT dr^v (uevr^QnvňnvSՋMOv \ُNRir>eVN"<{ \O:NT~epv[Rir~~~ۏLvsQՋ0_{OYu@b gdmh~{TmmNOxvzRg0 5.3.4 ՋRirYtThKm [Nk*N[~ ^(W[eY{kՋRir 6eƖ@7h ySOb'`vňnbvirv^ۏLRg0jR NkSRirvSՋMOvNS[^vzz}v[gqMOv R+RۏLՋRg0SՋMOvSRB\ S\҉(B\N NbvwvB\Ry NcOSՋirR^vfYOo`0(WgkTvNkeQ hKmSՋirvR^ \cOSՋir(W҉(B\-NlЏvgNc_0gTnmvv^Y{kRirT ^ySOb'`vvir NONvRB\Yt0NSՋRirSO NsrR NSՋMOvvv^(Wg N \ϞD'`ag4Nvhb {S ag\R҉(B\|D Neg ~~(uag͑ Y|4 v0Rag NQ|DNvhb hf҉(B\]hQ萻Sd0\ TNSRirv@b gagTv^N*NUSrv[hV-N ReQ~~mSmn҉(B\0 OYukSRirv8\SONOՋRg0(W[Rir8\SOۏL8T6eBRϑՋMR k*NSvv~~GWSRyUSrۏLՋ0N, N[8\SOv;`+TϑۏLRgsSS gvQNxvzc:y _NS\v~~RyۏLUSrՋ0RirY{ke -Nv?\m^Tv^0RHQMR6eƖv?\m-N0dkY 6eƖNN"<{-Nv|OT <{P[TUcňnGW^Ǒ(uTvnBRQmv^6eƖ vQN\o(WvSalgNhV_N^ۏL{|e\'`hirvV6es100%10% QV6esVv^ft1u0k*N7hT@bO(uvBRϑ^Ǒ(u[0 gHevelۏLRg0 ~Rg^QKm[k*NBRϑ~vs^L7hKNvOP]0 6 pencTbJT 6.1 penc 6.1.1 ^[kSRir(Wk*NS7hepvSՋirTb N"irۏLN NKm[dUS*NRirvpencY NO{8T6eBRϑ0*g8T6eBRϑTS8T6eBRϑ N N TS7hepvpencGW^ c~bJTvQs^GWe\Sf[~^ ]wBg(ybS]  - irt'`(0irtSf['`(Y pH0%cS'`0n㉦^03z['`0RP[ϑT4lRM|pelogPOW  SՋirv6RY  - MeTO(ut1u  - SՋir6RY~Ǐ z0O(uϑ00RvSm^0nZ03z['`TGWN'` SՋRir  - O(uvy^\/|  - Rirvpeϑ0t^T'`+R  - Riregn0r{QsX0re0uNSf0O(uSfI{  - Ջ_YekSRirvSO͑ ՋagN  - gkv~Ǐ zSՋMO0Rgel0T/^T0SOy0cS0hKm   - ߘirT4lT(v~Oo`0 ~g  - NUOk'`ur  - 8T6epencRhNs0peϑb~vRkh:y   - Ջv;`SOV6es  - ~gvʑ SbNSՋirNUOS_v~v8T6evpencۏLk0 ~g0 ~0     >$>2>:>B>H>d>f>l>n>>>>>>>>>>>>>?? ?$?(?*?,?.?0?R?T?^?`?~???????? @@@@@@ @$@*@2@6@淩hTfhPcOJQJaJh9pIOJQJaJh9pIOJQJaJo(hTfhgTZOJQJaJo(hTfhtSOJQJaJhOJQJaJhOJQJaJo(hTfhFOJQJaJhTfhyOJQJaJhTfhOJQJaJ56@:@P@T@X@\@h@n@~@@@@@@@@@@@@@@@@@@AA8A@AHAPARAZAjAlA|AAAAAAA浿̿旆s$h8 hyCJKHOJQJ^JaJ!hQ@CJOJQJ^JaJo($hchy@CJOJQJ^JaJh9pIOJQJaJo(h9pIOJQJaJhTfhj`^OJQJaJhTfha5 OJQJaJhTfhYOJQJaJhTfhyOJQJaJhTfhxOJQJaJ*AAAAAAAAAAABBBBRBXBnB~BBBBBBBBBBBBBBBBBBBBBBBBBǺylyyyyylhTfh2`OJQJaJhTfh,OJQJaJhTfh /1OJQJaJhTfhWOJQJaJhTfh;JOJQJaJhTfh2^OJQJaJhTfhyOJQJaJ$hchy@CJOJQJ^JaJ$h8 hyCJKHOJQJ^JaJ$h8 h;JCJKHOJQJ^JaJ*BBBCCH@HPHRHVHXHZH˯˯veTAAA$hTfhlCJKHOJQJ^JaJ!hQ@CJOJQJ^JaJo(!h!@CJOJQJ^JaJo($hchy@CJOJQJ^JaJ$hTfhCJKHOJQJ^JaJ$hTfhCJKHOJQJ^JaJ7hTfhyhq%pCJKHOJQJ^JaJcHdhgHhgh/hq%paJ$hTfh CJKHOJQJ^JaJ$hTfhyCJKHOJQJ^JaJZH\HbHdHxHzHHHHHHHHHHHHHIIIIII,I0I8I:IǶlYJHhgh/hq%paJ$hTfh/CJKHOJQJ^JaJ$hTfhlCJKHOJQJ^JaJ$hTfhECJKHOJQJ^JaJ$h8 hyCJKHOJQJ^JaJ!hQ@CJOJQJ^JaJo(!h8 @CJOJQJ^JaJo($hchy@CJOJQJ^JaJ$hTfhyCJKHOJQJ^JaJ$hTfhA:CJKHOJQJ^JaJ:I>I^I`IIIIIIIIIIIIIIJJ JJ JннКЇtatNК?Hhgh/hq%paJ$hTfh}aCJKHOJQJ^JaJ$hTfhlCJKHOJQJ^JaJ$hTfh/CJKHOJQJ^JaJ$hTfh;CJKHOJQJ^JaJHhgh/hq%paJ'hTfhcCJKHOJQJ^JaJo($hTfhcCJKHOJQJ^JaJ$hTfhyCJKHOJQJ^JaJ7hTfhyhq%pCJKHOJQJ^JaJcHdhg8IIIJJfJtJJJJK$KtKKKKKLLLZLbLfLhLlLnLgdyd,WD[$\$`gdTfd,WD[$\$`gdq%p J$JKDKHKNKRKVKZKннннн㽛нЈнннuuuuu$hTfhn9CJKHOJQJ^JaJ$hTfhTCJKHOJQJ^JaJHhgh/hq%paJ$hTfhS)CJKHOJQJ^JaJ$hTfhyCJKHOJQJ^JaJ$hTfh}aCJKHOJQJ^JaJ7hTfhyhq%pCJKHOJQJ^JaJcHdhg.ZKtKvKzKKKKKKKKKKKKKKKKKKKLLLLLL L"L.L0LbLdLhL‰vvc[Wh0Ljh0LU$hTfhCCJKHOJQJ^JaJ$hTfhcCJKHOJQJ^JaJ$hTfhaRCJKHOJQJ^JaJ$hTfhcCJKHOJQJ^JaJ$hTfhQ]CJKHOJQJ^JaJ7hTfhyhq%pCJKHOJQJ^JaJcHdhgHhgh/hq%paJ$hTfhyCJKHOJQJ^JaJ"hLjLnLpLtLvL|L~L$hTfhyCJKHOJQJ^JaJh0Ljh0LUnLrLtLxLzL|L~Ld,WD[$\$`gdTfgdy0182P. A!"#$%S &Dd!  JA(8 vgk:yaVVGr 13"RJ4G*aלY{ã&DtF4G*aלY{ãJFIF``ExifMM*; JiT >Mr. Wave8787 2022:09:01 19:58:062022:09:01 19:58:06Mr. Wave http://ns.adobe.com/xap/1.0/ 2022-09-01T19:58:06.869Mr. Wave C   '!%"."%()+,+ /3/*2'*+*C  ***************************************************D" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?F(((((((((@fHsޖ ( ( ( ( ( ( ( ( ( ( (rٸnqqKL0gYjeU*m8$gӁS((((((((((((((((((((((((((l$QFK1:Ү kK3LdG?%fL:5Z?#z6Ic K1ž@>$-Gor93hUIę^Pw#zo|a5It6Nɟ⿁-,*A }*4g"ܹS_+n!źmҀ\_1z|)Ođ MGb*$2=wASPmq1wc$LJdw(Z?U:Y 23rlA Ul\+IeSE,v"f;s|#oF:+JP4߂9W•ӬN Z!?-3CBOx\{xK%xW~P|׺uviOa~.Mͤ0ѥdv7TP(R⇉<6Xyoz ˷K-'h:x牾9jz X+w}ZjzNJ<L-3CU yoָkb71xOKפBʋD?'? |j%)ԒkI;B^X`:Vޓ*h+4 q"\1xld\%Pՠ wzN7DI'NXn3ZyKvu/\556UpOX tQ1DQu$.K~_t}GJ(ښ4? +tvhE]5}XbCa@g9Z4mmZ~|=4zėgA礜 m)|x7d>I$K.wv:z}*_A&teL `L#q̿е;]i'zwvPK ~r1R^!q6v0L!`ٓ|W)Xx *[Zmd^ ׍[Kv`!G3ѽ}@TmN׎ #t߁|quciuf+F "U{׉#ѼL xPi2'x9 H+&O< kw~cWoa I|91z F<%t:n؝3u>Ÿ/*fu%du'~;}欞[i XgY-28*]<c-@/af*Q^Kx^ašC}GCz6<$G#цU@(((((((((((((((((((((((((+ky'u(ԻMI^qx&AӘ߈/є1˟c  Io r2fhK>쮧vqmח,6$vIt]&B;{HV$U g޼֫s|,6on<ːC%K'p'׵a͝זv kBW{`6NAœZO LO|'*:?suSBv[/#NKv:E8φwK:~'@0xz69DY92g#֣DME߄|ᥐH$2/̙9_==4kknsªS`]|рO̾߭YM&}Rb _pJ"qNkYf:-a6|/з5i'xwx]$#eq=ka<;d_J`\8 ~sos@1BIx1^&܁jKo3>fx]4vSUY_(wBVDeX!|=;UTBf@]7 m&C̘_q4E*)x$m[w&:z|`NLVVݳU !4 p>(%O<}GӚ:ƞ1-acch?vNᘆ9ot@kzd1n1[Z__RzdP0~Gall$7>Tz*MKB$ZO;ʰx_o>VP3~@"D5Ŷ{eC~QM^_|oy'| Ӡ[ZOv5PsS ;@^z^}[]COk<@۷nz|Y<aCH\Ebxu?b|b3xDYC W\џf}q@Me _SͺK ð}}H%4rv{s~S(3\Oe̗K<9#do^$1kjBS%<#facs~GJE \e7xr6ޑg:Tiu"2cZyvZ薒o /pϿO4hvo<;|7L &xpvoրy:Z3ds"=>V (›ϕt |}Z6XAʞiqcˏ3ڙh7¦Vx'k/jm&  #}lCÚm goF F5lڲGᕗos?Ҳ5.F]/1F<x[@A^fE\{t8 ;=c~l#ĥtǥ@#ݰbNa9_ K $V :gFns' 76>_Rjp[:_X[%.9s4n#x4%mݼZH>k/Nv{kx9NXjO\fM&ɐ߽ӌTz1 `>?v_p04G^7ZJgkH'(Ǖ7UV[ Oyc;GT vo+ ]^1|?\\xTnT 01q=(M~񅿉o$5 4rr%WI-~s^$mNoJ_m}1 # pzq\vISۿ8PPD>)]x6]Mյ9An"zSk>fɷ-zO^xLӭ<9-坳j7=4fb8v:@&K_3JIq.С*O7X|VRzQWqegaogh8-XA*~BE$eSnu-Mq O9ǿtcNm/@ͭ5kfyrUu;]GO,.}8} |%CqKD pzimQڏt gs?QPQ^}/ 9KGH m+~h(((((((((((((((((((((.!T9¨I5%xu/]2i#'Ml}Q#6\ѩMeMx&=|$ODW^3ŦvQY0OR}ZӬaaqƃT S^OtGoQ^^QonPgA^j }=_ olyB/@jѵ?T:uݤ$>Wv˥-wNw`y=0A[[}\Ky2= ω}7|#&6)+F: Ej~%3?z.FHz 4/]2ѵt@ڵ|a~: csgϺׇ&_ i%5G4`!0=ϧJSY$/\X۶/G_lT"+#i^ۢ@RA92 2E]o$^v|{ M[M;)Ѽ^0/=GN.m"M~Q"Nn~czb[J*c N'}Ԛu,Z']+_(t A"b|![~@/[?SO`m8GNݪƵ.WB$_ 8n iXUtV"L?{*]gLmɉ<Ņ6h:1O_[ !<h3Ձ-=}t/^4C}Egya .`0$[̈w`z ]~_RM_wkmm w@wĝ{V֏.}6ZV"&sn,r:z|xAM7D iN4O hҴuGw?E"'᭬~.D!x wK E ڂ?{o'Uy^Z8F=OÈytNWWJdy3qrc'W$APB~?#qO_z<:Cx_K*r D7ydP0Pr1@|xI6Tf>&n̍Wk^~1f٤0{?^X*^e8h۳)ElQ^iz?մ] z]QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEp7k RToc<Ylmrr&s%H>E,sqsZZK>ԄU]~AQӷ<{OE.w5xvaV$``3]Gﭮ\L \g(|gok=d΋:0gY|F\mni 4P2RNzv7~abyZYX[9€6S5h='~Ff=N3P Zv2ZxB|3tr \^*r3j񖟋[3Xq{QԼ=Л˘.`d(! ʐsۧs/rmΥ\ib t;{#fMi0 _'P<3D=PP,玣mi_<{۳h^=QD\HqWcbO5In;qcxu1YlB| k&acxwlk Т*p|H?{&1 EӥjDC1c#=R7ŭn-o#7 ybQ-~F 篰/~|M^?n/mb_Q2σ^>6go'f_\TԸ6?O2/n㟭y_%]O%֛ ݲ۹6ɈWj;ۛ|S,jJ8OO*׷cx$ހ3ك,j [^Z  [O+y3mמ^7ĻbMcoTKNrMӾgS#ma8T^z֠N>cϦ2=1/¿ضMp3MxSB:necl1W*<sVԷZ=)%ԑE^0{$Z.n5^x&_q;w[[C Km;q?*yhi! ,umzmBPIM UPџBdQm׮.CDj=o~;? ?3{g+2Dݔ s=>ӥ9c (cs^_ JG"uSj.H"m#БPY?61la |V64ƨ =QE{tFᩅɐe?C5hzjMs ⧽{Ib6Ǩ#מ| H>.ڍ͒9#BJ((((((((((((((((((((9fch֬1צWψk%W>\((e X-m-ԱI7,$${F^Ⱦ1y&XA;:ua[skp%A׎gĿ O [?#&^]*F=c$ezZ-: Վh4C-?sS.iZGosx-V6ˇbGx'֡7h.bD3Iȫ#=1d9qOq@ ikio^A#$HlRj0$3=9Ͽ<{Z,[  9Y&֮5nFqb1'H5hhfm]$\DİB 摭5U홆ECHRin>c9*mI۫Ihi"&MUXw5VV~yX7g^~;84t[D3iEf8y$ оoXG娶7W88Ö y/muDo2& r3[XYkʺ,rĬUʟ@@tPilm#6n A$8Z[O&h'@I8'ǽ?G\n$m[T֢:^_G\y&1o( Uڀ2mtiz.Qaeۑ[o6g2ZΆL'fZn8ur71^*毧򶜰,eIVS4jZiilǝ `W s55\ֱ@m!YږrkY@.I xsGv܂ҪBRzzP~&{-5ao ܏ާY[m-.U@v 60y+?No u\::tRģA{n MB[Y_K.8Or_O+ߛK]"K1d@0+H=- Gg5ˀ8N=k~+^xm ~# w$&q0p?:ttTUO) ޜc]; Mp=e̓r-+xCWmԱY@$ 5a"LF8;]N]ѬCui"ч#%gum$MB}eac٧k Uo,zddҤRo4-&Ֆձ 2lT{m-9+is}o+tOA皊_x[>MR:c|z 5ׄu ΍68GzVƿ .qu"]hv]>TC s@΁g#+ !RVsػZn`/B]^|J!7^סx/5/`=LmjEQEQEQEQo_ʝEA+_r[ HBR@GE)h ( ( )7gnyǭ-QA8@6Yc&gXAw8z\/-:=u:a#)m(aGC[7ٺ>O5r~Tk}FO|*_1s ȵmAx{ß 'y]O J[O<-j:~xS͟Vlc%*XᴝXxVi7M[NAYӢc֑\|H=@󧑢?[{n~s͟^HB@t((((((((((((((((((((( {_tr;YG) }A}yO#X2x|bW >xW5q=:Ei+c5-`zp}{U/ʓZRf;^=@ÚawNBFzq24QEQEQFqր *Σef͕W?n⧁E׉ôS ;h8^pJ>?NFGNj>&k<m_}^8 z?7"O+7YVzŕ8eR~$Ǻ?+얰 ZpEj<\-҆z?Qsq!>7qv}bF߅?AvmA.Ȫ4J6-tԏHPGv3UGk/{{jdX4ހ'þ|#bm 63˲/Ǔ/⏋V:~W/[[3>8_YG$MOŮٯ"\L9J xteJU/"^#ہդ\ I~0CV m˟-1?exwMzBn.dǩ?O/G+K.23n-s<M] {N62?fK6'L5= ښ!Y>az8F{UG^4/vjIuOk 5HI!뷪ǘFGt^&9bG@|iSmK]Mp/է[ֱ&qk,->=['a *y[# C@V,0Ю-tb۩2-rz=}+FPtk(>,YV%5(C%UU,z6uC{y#)#Ҁ4(t=MK)'=3-Lt J5-+m.;vCҀ7(wW4l}b [/+,3 *-+P.xI#ЊӢ(((((((((((((((((((((((㵟jڜS]X=4w^z麥Y>ϖ$2 9aTYJc</_ x^REiMqp[tAڶh^H?uX?LM]kǍ6)&66#pcErkxV MQ?z^7k|;,:G]Mʮ0o4}ESNoƫ9?п>=E(OGǿ/35G_fj(\crt;[+3j2ˮCD'M3hJT/j?:,:xl# @5 AmMm5?wڪ2cK{ º`dBИ$˂w)CڤdzcRX^mGTu6ɖ$Q__ڌWOmnXMsp\"rew? v?mdU^f>~MxV%~67rڈnDT.W;񗇼BYsKɖe"f?8=((((((((((;o# EyX 9k_/i`2u=4WM$m/]<<d/I<1]Z1!wdj3KP`=@8~UkO670!$fe88<+~-|CKhj 4ihqݙ!x{EԵo1An䑵D`c'daJ>+jUmce# z։ҫ.ᔌ4mq33{h/Œy\;<|%wW|X>?Ə3q4Q\cxK<ϋ_yEp+nǗ=J_8g?h`sC{vヶ4Q\ [WY*glf99<3/?z :^stl`_𭽴JYEU-\奿Lq6Z3J6J-%C|}3C@}޳m'³Ie]=b&.-;H[{hORIk/xON-(Ѵ*ڛz{Usn훁ipqgJ ++r_xL< $^>wrWLy b)2=׵{cBRY3sP^Fʚ XLQ8zP^}&5:4kiX$Q.sW'Ih5$Fb]J~c(((((oz'}ַW3DڤhFk11eι$IQ=7>/{ڏ{VIRd 6՜mRwtPbGZޗ[]B;x1?"<<gqqwCm|7 'WP^ $NmnC"`r0asKgg5|&ncYO,m0ZUyK`0^C޽B((((((((((&.>[Gw)&Ԣ ]M/ö8bx}rI< b%?X7` ]cEYU/S"$q8juiq U ^yr]u~W<UuO[h졈ZI2w?)ګOk{!7]p㍸<{cҀ(W髋m@V,і5*&Q1OJ* :j$&*Xe=Cր4I4?Z٢O|2':^G@J!? +? r?#k hr1_ cҿ2? 53AUO1oazO>'xWAgٱts@ڼ-?D񆎚1{].;ȝbHUbN>Pxh,tKǗ jV[r$=tv焓ni#pM֣?Numր<ix7!vő95Zyq[ gk?᥯/4OEtS ハs:W%C3C*Tpv lڄskAEQHU Hm<* {$obЎs\ 6=ϊXT,Y8INWt? h&p#ހ:MZ}C%edII\B8sfO+`<;VEP_,ܒ^5g<;sie8 "ʌ0}L~{XԿ";Insd7th7:ίI5D4-TA;s}z~i( X]e6(v^ ͳq@T*HNmGPk;tyѠ#>`yALPEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE?::V qIwq%,!Rf!x'+1Ẋ =O5ueṵ_M,F1!,  /nqր:{qo.]W20ϡo :F^\˝$yW޷ZWW2 3{u&d~:YUbH{4I%$ܼP_*s{bKŇMKtm9l\;3I8 )HʬAQ9sI; #I 2nh#Y%I+n8<֕n{Dc1km$>ҠS#,H! <ߩ? X |bpYNqS] NH<-ۏj3 1!d8y);Y-i<V-m1z09Ud\7 hq^jPjJ V(rd*6/9cNcѼȣuzzYj5c;Y2995!6kUx9_[*]NAc<`) s~D*d cKWdϵЎDc5"A [¶D"'$m@PF6zs(֧G,d[!qӡs*ܼǽ( (K$oNAqcr,+<6צjoIݴv1:q0>ei6v<~U; 62[-Z9ARwcWé+L:/5?u}+YtV!ool"xe<@7k3yy$?(eaI;w:LO%MDi;TaW\"4feLj$^Igmoڦ5.qdQEQEQEQEQEQY~" 4ԵFu]#;,K0Q$<my%‹Z! wn X _Ed\xIn4.swmmcT'js88EBռ;aE%,"{s@W |zݛ T-y1q Ku*Q2ZF%ʕܧP( ( ( ( ( ( ( ( ( ( ( (xC.-eMvCy> 7^oj:g}L$ .Cs{ I3Fc$\G' LS3kv@“sBUp~/_ -SC-DHn zf|ExV^Gv.FPS\n赯vL6mܣ%e_u(9' .'bNs# Tn|%yck5>hsg k_iMiwSAl7Eܰ~bAaj5Ѽﱠ.#Eۅq ~+V{kwP^4ҫ6c#jå9K"I[e0:`Ko9$K|;=I.=> <@q*O5Q@r|#G"/$$ 'TMolτaڊTx0oDt˪jy]F9>4 OgP ?”|. O𮮊Vx )Wx?+9?UGG4 Ss4 Y>xKG4 / O}?º(qཬfGӓT? |5?(üai||g髧Z1nsO^y T yG)#@yd 0_9/^_h48" "WYI#vqZ YuW!z+q.c}^XNaKh|r{w>/<4!A~|P_ko*x[–Q-+ OCt>PپKuO#{cGg3Tn3jOm\{x:=ޞ4+'9 PGI-(2xz=kZlG*mXdڽKu12\E~n? 鿴E mla6}tOpG0e-62:SѺW}ND2dYJs?_S!nz #Wioo^^5Qb*8;B<ɯg}'O;,!hdǵ?iy%_Bz@+Z 4Kv[ cBRϴ>xfpG\WE"Qa*ZQhb BF:'N*"j0@(QEQEQEQEQEQEQEQEQEQEQEQEy! lH?7yE<'VA. 30,rrqC((((((((Ǔ52%9~qߊ[K5kg✂! 篭y_-gLDZ8ܻ goƽ^+{XFth+!/-v&yјY# 9c/xTulT*:Ff` r:עVKY *I`0ӭ]Ub(ebnw|\ ?m2yu٤8p"d0= .gݥ˥MHlC)l[סZ-.+,MZ>aE)31>@_دeʄi 1zO~yWj88߷+iROz/SFK.*K~ w+lnﮥis*BcߌW-!JfM& T?4QEQEQETqO*ra}C%QER3RB$JeNAހ (0ʐG X|ּ'miYĂe*N?/sǯր2~?ڟc*bA'd=|?/.Dɵ-Btlgį;D>2wt_@˒zrkX7v${`?;q>'&Jk\KPAr#qIڡm T[,@ѫ1ޟgRN+CN#{Llq e;ɮɂr$# vF:4|hYd{0N\zMy_$)pѦ䓚Z(((((((( (;9?/]\[5~ /!iXѰ=@jH k3S 0?*MZkvr 60$O#=(_~#޵-)X3O#^mMkP/~%kzNϴȃo{1k>+~[VlE?TW_iB6ۙs'o;kHѭRXdjҸeZz6{xR7pyepO'}>x8x^-&Qfq̣#sEw#[u\0hkp?LךXx>;xI'KLNG%tmA,xL:2バpqzX ŠDɸ PEQEPNO|c]A=j*Zt86þ{1jrACLp1{M:YcC}dzSk-h. |{WAiNoD"GP0*r_4oֿOqT4˽V i^|lM*eX]M|kկto֚Ȳ4bܛv7 wY=SV`gIezOӼ-wwφ1ӟ2j\ȡ.N1uO^WPnc@`8f;Ag?1&M2tX1]@8x>ZH=xB;kg%nvyBp] R&F72j!5-Rٞy]"f%QorO=~$WH ]nѴ^hM0.s"68 ' y %žY9l7xnS y8vsҽ> ( ( ( ( ( ( ( (O_R_ d}=k/mn85u(d;k~9z>:%U~'O6zdgŽIN9=o5^K}M7lq^ mYKų|}oJio3"ۮ3?v͸z“7zE3Ϛ?i帊 ᢒݷ0x_oM#-4NQd[>Ҁ=g Xenϧ\\F|<*c<+-_ jQya  0JZ#C5}xYbwKybcafր1~tP0!s{gҽ*xFY/ ;uo: ( ( ( ( ( ( ( (5oom72<2ӥyaCPH ppEz.mz.%Ky{ +lf& ûpe 9^^[r!kx[T-58&ah7Fc\d+GJۮI{š{K@S,`pzy3RPĐ쀙8T?ᤴ?2WK НO@|j~qcqW'_~ Pchgr{d&h3xf:g?Lҏ:ʼn q@Ex,x/[DAi$~+g;c4>&\Xxz \۶eGl'$pk1iu?$HI |S}}sQnjT].\+/LѴ};NaG([>"E".U;3=zWiwu7b5Q@Q@)c='Wӧ©q% v\g'$zGGWuoehd ]ķ*xG!R "e;OpvAj֍ ML.촩v >y :jImq&RxK"y#>Wqƒ7nשx/3èJSY\Z7'UȓrIs~}njWrNݦjV"6۷h7gG𧆭tU}/p*.?)؏Bd`y9/hNzp\qiyfbPC8lt3\uZ&Ԧ%J-CH–P@ېGzVńַpA%jˌF1\Lm\ ȭ'T|-p\0Yrs8sK_K4EW6PnB`,:3Auk?)]Ygl_*.~$|E{+o oc-)2乞H7[%J6{}+H,uyaǓY(6~`Isg9CD6Tǿ: ( ( ( ( ( ( ( (|"נI9"H][('ӧJO ,d4R2j͕8q]n_u u"R˃yj.'{+\QIo@n7FaYM17ڨ!8(NxZACF63aOU_*(Ydc~A jݢجƾLL )@΍AS=Hi%Wz`rs6'0OmY=3ߑSk6MKNS27qc74kkѯ%dA7'qF'wRZǛsl4jMBud~ybr6$^0OJ[/djōQ13AsֳcuKu 11wh~ҬBހ(~cGu;:|-±`o$obEzQEQEQEQEQEQEQEQExFxE6c*/HL[l1n9r^O>M;ˈHf,ͅNONOw|Cyi|ET[>ˬz| ylfȬp3.ѷG7*$s g;cֲϏ7ϯiڬ{ OS?xßmz)q U@z*LcVL@$:S/dʚFipIgjOO-C/ =tU~#[h>;tQR (zU-W^|Xʣlo*cd$p:[^4r5]]C!xdŻ8K C5=6OYu0 0pNyk p^|"𦩩"Kdk;ckUgl4RN=9^DaBT rGОimp$) kx؁Lm踟HPLrۀWVU/qw-.f{ٵbEImPBAnoZ[M-Hb `ڀm'_ jsj MGuc{5Ak4 PY(wՈ(vZªs#9ҭ[ o~aPàQ@Q@Q@Q@Q@Q@Q@|w< 4]=\Dķ^C 8H?j`i=]^;}# J)(=.qfvwE(LU38O157-+'t0} sjScxwGٜ 0\<娠O+`A(D"O+:/^z[?KĝBŧizebw5r&z7ڸ3:J,l[8lv^vv{ ³BXF¸^6@6d4Fh5r/z:c[ib[lFrr~\qPhc4iVQ&=MhI|E?J(᤾"_ҼOҀ=[K/S B$fWP 8h֏wPXOZuKwl(+f}=[j!Age9Yc=(1[K'ǿѾH39g洬Ib[$z?/?Q 7`d('=#o( z:uuK5{R$q3*"[H] M$9ZhW8Yl?M :[-j?ak]sztx*G`p ( DkEmt,~^P.z'U?aZ&H0 ~rP\qe_+(VrIqNo2WWK>~^*eg4*P_UQ@)SG27~Omc_3Px[7'nśے~ܜk(d۠[0v-I4L-=~Jsm;Sx-OTdXkm m_JQ@7,mVs/2Z(kCY?ʾ>oK_T% g*Bei^^<>]űNj!&/Xs ?ʾ>pZnV?ʥL<[<_EQ@=왥?[.?8~ɺ?9=^?ѓk*(&M|xnSE+iE,IIc@uXP{cO|E >X3o,tջL:TJ((7Yx n-mKKuDd߂brqfXiNY0'MI*YK׿zhIE3Q5?)-&)2r@ú b,.|u/ʽ>J((((((((((((((((((((((((((((((((((((((((((((b 664666668 0@P`p6888 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~PJ_HmH nHsH tHR`R cke $1$a$(CJKHOJQJ_HaJmH nHsH tH$A $ ؞k=W[SONiN nfhxjm)ʬuWLfdݮ+5_4csj-V?k3rm}gz gs嚋7xwsȈR W*)|jȫKXͫ dXIBF؇bnh ( *'vɗ3KZjz'c*_=}<9ݻw~]8^~_o?xYýg~^G}J0Emh=Ԅ Ξa>s$-, Oɠ=Hp Ua/ UO d*:(.fTU/!9$V[|hrvs-iUt. 6ڪ4Cebs)bMjBekp um,fd$͑{6GUVf~b#Vb@qTTW.ޛd)i@vdq9Y^X7{2%uHx+af6]>f#sm*qqDHehK)@?71oggo`:fղekp£2֌Nj8ǰD CB?81e>nEeU}H]dm1iQ6褣֧ ?l hD 8  6D|Z >6@ABEFGZH:I JZKhL~L '()*,-./0234 DE8InL~L+15@ @H 0(  0(  B S  ? _Toc436647222 _Toc436648566 _Toc91681949 _Toc410385819@@68h}JN+,89W`hrsyDGJKPY\^bchi 46>?JKISVX\]RSUdx}  ! $ / 2 7 C N O R U ` d   V W ( * D I O Q Y _ m r y  6<ik 35=@CDJV[b|~ &+-0134679:<@2HI  o t 9 < ./134679:<@s33333s33sss39Eiq dl&0134679:<@}jX9 rM&-,2aRtShd}Q|E p 8{  & ?; [ } a5 nR eS [ ,|^T H?<cDsFI&L1B2|VS !!/j!Bp!4"V#YU$Z%i(BR*@-E*.T.G / //FF/u/.0 /14P2=@A2A$zAM@EFGHGoG3I9pI J;JYJHKbK0L,L"M^OMaMN'N| PD:PfyQ^3R[RJSASSVSjTgGWNXUnknowndell780G*Ax Times New Roman5Symbol3. *Cx Arial7E eck\h[{SO;= |8ўSOSimHei;([SOSimSun7.@ CalibriA$BCambria Math AQh#‡-&j j !20)) KQP) $P#2!xx JYdell780Oh+'0P    $08@HJYNormaldell78045Microsoft Office Word@dN@LZ>@B*jj ՜.+,D՜.+, X`t|  Microsoft) (S[wKSOProductBuildVerICV2052-11.1.0.12598$CA5E2363B2E945B9968641087D87B42E  !"#$%&'()*+,-./012345689:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry Fo^*jData 7&1Tablek,WordDocument2lSummaryInformation(DocumentSummaryInformation8CompObjn  FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q